Mathematical modelling of eukaryotic DNA replication
نویسندگان
چکیده
منابع مشابه
Mathematical Modelling of DNA Replication
Before a cell divides into two daughter cells, its entire genetic material has to be copied without errors and exactly once. In eukaryotic cells, a vast amount of replication origins exists that enable the replication of the DNA to initiate simultaneously from many origins in parallel, thereby contributing to a relatively rapid duplication of the genome. The initiation of DNA replication from t...
متن کاملDNA replication in eukaryotic cells.
The maintenance of the eukaryotic genome requires precisely coordinated replication of the entire genome each time a cell divides. To achieve this coordination, eukaryotic cells use an ordered series of steps to form several key protein assemblies at origins of replication. Recent studies have identified many of the protein components of these complexes and the time during the cell cycle they a...
متن کاملMaking sense of eukaryotic DNA replication origins.
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA seque...
متن کاملMathematical modelling of whole chromosome replication
All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins. Here we investigate how the activity of multiple origins on each chromosome is coordinated to ensure successful replication. We present a stochastic model for whole chromosome replication where the dynamics a...
متن کاملStructural insights into eukaryotic DNA replication
THREE DNA POLYMERASES OF THE B FAMILY FUNCTION AT THE REPLICATION FORK IN EUKARYOTIC CELLS: DNA polymerases α, δ, and ε. DNA polymerase α, an heterotetramer composed of two primase subunits and two polymerase subunits, initiates replication. DNA polymerases δ and ε elongate the primers generated by pol α. The DNA polymerase from bacteriophage RB69 has served as a model for eukaryotic B family p...
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2009
ISSN: 0967-3849,1573-6849
DOI: 10.1007/s10577-009-9092-4